金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:O60609 N-terminal Sequence Analysis:Asp32 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:64.8 kDa (monomer) SDS-PAGE:75-90 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.Immobilized RecombinantHumanArtemin(Catalog# 2589-AR) at 1 µg/mL can bind Recombinant Human GFR alpha ‑3/GDNF R alpha ‑3 Fc Chimera with an apparent K_D <2 nM. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: GFR alpha-3/GDNF R alpha-3 Long Name: Glial Cell line-derived Neurotrophic Factor Receptor alpha 3 Aliases: GDNF R alpha-3; GFRA3 Entrez Gene IDs: 2676 (Human); 14587 (Mouse) Background: GFR alpha-3 GFR alpha -1, -2, -3, and -4 are GPI-anchored receptors that interact preferentially with the GDNF family ligands GDNF, Neurturin, Artemin, and Persephin, respectively. GFR alpha proteins initiate signaling in association with the receptor tyrosine kinase RET and by RET-independent pathways. GFR alpha-mediated signaling is instrumental in the differentiation, migration, and support of central and peripheral neurons. Alternative splicing generates multiple isoforms of GFR alpha proteins.