金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:P97378 N-terminal Sequence Analysis:Asn24 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:95.7 kDa (monomer) SDS-PAGE:125-145 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.WhenRecombinantMouse (rm)IL‑12R beta 2Fc Chimera is immobilized at0.5 µg/mL (100µL/well), theconcentration ofrmIL-12 that produces 50% of the optimal binding response is found to be approximately4‑20ng/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: IL-12 R beta 2 Long Name: Interleukin 12 Receptor beta 2 Aliases: IL12RB2 Entrez Gene IDs: 3595 (Human); 16162 (Mouse) Background: IL-12 Receptors The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.