金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, His28-Ser748 ( alpha subunit) & Ser753-Lys946, with a C-terminal 6-His tag ( beta subunit) Accession #:P15208 N-terminal Sequence Analysis:His28 ( alpha subunit) & Ser753 ( beta subunit) Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:82.6 kDa ( alpha subunit) & 22.5 kDa ( beta subunit) SDS-PAGE:120-150 & 38-41 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.When 15 ng/mL of biotinylated recombinant human Insulin is added to serially diluted Recombinant Mouse InsulinR/CD220, the concentration of Recombinant Mouse InsulinR/CD220 that produces 50% of the optimal binding response is typically 0.3-1.2 µg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Insulin R/CD220 Long Name: Insulin Receptor Aliases: CD220; INSR Entrez Gene IDs: 3643 (Human); 16337 (Mouse) Background: Insulin Receptor The insulin receptor is a type I transmembrane receptor tyrosine kinase. Ligand binding results in receptor autophosphorylation, and subsequent downstream signaling important in metabolic regulation, cell growth, differentiation, and apoptosis. Mutations in the insulin receptor gene have been linked to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus.