金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Cys25-Phe222, with a C-terminal 10-His tag Accession #:CAC05586 N-terminal Sequence Analysis:Cys25 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:23.5 kDa SDS-PAGE:25-35 kDa, reducing conditions Activity:Measured by its ability to inhibit BMP-6-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells.The ED₅₀ for this effect is typically 1-4µg/mL in the presence of 150ng/mL of Recombinant Human BMP-6 (Catalog# 507-BP). Molecule Information: TSG Long Name: Twisted Gastrulation Homolog 1 [Drosophila] Aliases: TWSG1 Entrez Gene IDs: 57045 (Human); 65960 (Mouse) Background: TSG

Vertebrate TSGs were subsequently cloned in mouse, human, zebrafish and frog. TSG acts as an agonist for BMP signaling by modulating the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. The N-terminal domain of TSG can bind BMP protein directly in vitro and shows BMP antagonist activity.