金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ala33-Asn325 Accession #:AAB51298 N-terminal Sequence Analysis:Ala33 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:33.2 kDa SDS-PAGE:39 kDa, reducing conditions Activity:Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. Ko, L. et al. (2002) Exp. Cell Res. 280:280.The ED₅₀ for this effect is typically 0.05-0.25 µg/mL. Molecule Information: sFRP-3 Long Name: Secreted Frizzled Related Protein 3 Aliases: Fritz; FRZB; Frzb1 Entrez Gene IDs: 2487 (Human); 20378 (Mouse) Background: Secreted Frizzled Related Proteins (sFRP) Secreted Frizzled related proteins are secreted glycoproteins with homology to the Wnt-binding domain of the Frizzled family of transmembrane receptors. sFRPs contain an N-terminal Frizzled-like cysteine-rich domain (CRD) with 10 conserved cysteines and a C-terminal heparin-binding region. sFRPs function as soluble antagonists of Wnt signaling by binding directly to Wnt proteins and preventing their interactions with Frizzled receptors.