金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Val46-Asp218 Accession #:Q9NZH6 N-terminal Sequence Analysis:Val46 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:19.4 kDa SDS-PAGE:25 kDa, reducing conditions Activity:Measured by its ability to enhance IL-18 BP inhibition of IL-18-induced IFN-gamma release by KG‑1 human acute myelogenous leukemia cells. Bufler, P. et al. (2002) PNAS 99:13723.The ED₅₀ for this effect is typically 2.5-12.5 µg/mL. Molecule Information: IL-37b/IL-1F7b Long Name: Interleukin 37 Isoform B Entrez Gene IDs: 27178 (Human) Background: IL-37/IL-1F7/FIL1 zeta Human interleukin 37, also named IL-1F7, FIL1 zeta, IL-1H4, and IL-1rp1, belongs to the IL-1 cytokine family. With the exception of IL-18 that maps to human chromosome 11, all IL-1 family members map to the same cluster on human chromosome 2. Mouse IL-37 has not been reported, but human IL-37 is active on mouse cells. Five isoforms (IL-37a through e) are generated through alternative exon usage and have distinct expression profiles. Like IL-1 alpha, IL-1 beta and IL-18, all of the IL-37 variants lack a typical signal peptide.