R&D Systems代理923-AN-025/CF Recombinant Human Angiopoietin-1 Protein, CF (25 UG)-试剂-金山科研平台

R&D Systems代理923-AN-025/CF Recombinant Human Angiopoietin-1 Protein, CF (25 UG)

2025-06-27

货号：923-AN-025/CF

品牌：R&D Systems

规格：25ug

目录价：￥4220.00

市场价格：￥3376.00

会员价格：￥3376.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ser20-Phe498, with a C-terminal 6-His tag Accession #:Q5HYA0 N-terminal Sequence Analysis:Ser20 Structure:Oligomer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:56 kDa SDS-PAGE:70 kDa, reducing conditions Activity:Measured by its ability to inhibit serum deprivation induced apoptosis in HUVEC human umbilical vein endothelial cells. Kwak,H.J. etal. (1999) FEBS Letters 448:249.The ED₅₀ for this effect is typically 10 - 40 ng/mL in the presence of 5 µg/mL of a cross-linking antibody, mouse anti-polyHistidine (R&D Systems, Catalog # MAB050). Molecule Information: Angiopoietin-1 Aliases: ANGPT1 Entrez Gene IDs: 284 (Human); 11600 (Mouse) Background: Angiopoietin-1

View Angiopoietin-1 IHC images. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are two closely related secreted ligands which bind with similar affinity to Tie-2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 cDNA encodes a 498 amino acid (aa) residue precursor protein that contains a coiled-coiled domain near the amino-terminus and a fibrinogen-like domain at the C-terminus. Human Ang-1 shares approximately 97% and 60% amino acid sequence identity with mouse Ang-1 and human Ang-2, respectively. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

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