金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr215-Glu673, with a C-terminal 10-His tag Accession #:O35598 N-terminal Sequence Analysis:Thr215 Structure:Recombinant Mouse ADAM10 is prone to proteolytic cleavage at C-terminus. The predominant form of the purified protein lacks the His tag. Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:52 kDa SDS-PAGE:60 kDa, reducing conditions Activity:Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH₂ (Catalog# ES003).The specific activity is >5 pmol/min/µg, as measured under the described conditions. Formulation:Lyophilized from a 0.2 µm filtered solution in MES, NaCl, CaCl₂, ZnCl₂, and Brij-35.See Certificate of Analysis for details. Molecule Information: ADAM10 Long Name: A Disintegrin and Metalloprotease-like Domain 10 Aliases: CD156c; Kuzbanian; MADM Entrez Gene IDs: 102 (Human); 11487 (Mouse) Background: ADAMs (A Disintegrin and Metalloprotease) Members of the ADAM or MDC (Metalloprotease, Disintegrin, Cysteine-rich) family contain pro, metalloprotease-like, disintegrin-like, cysteine-rich, transmembrane and cytoplasmic domains. They play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. Over 30 members have been identified and about half of them are active metalloproteases such as ADAM8, 9, 10, 12 and 17/TACE.