金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 9 (baculovirus)-derived, Met1-Ser426 Accession #:P08476 N-terminal Sequence Analysis:Gly311 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level:< 0.01 EU per 1 μg of the protein by the LAL method. Predicted Molecular Mass:13 kDa (monomer) SDS-PAGE:13 kDa, reducing conditions Activity:Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. etal. (1991) Method Enzymol. 198:340.The ED₅₀ for this effect is typically 0.2-1.2 ng/mL. Formulation:Lyophilized from a 0.2 μm filtered solution in HCl.See Certificate of Analysis for details. Molecule Information: Activin A Aliases: INHBA Entrez Gene IDs: 3624 (Human); 16323 (Mouse) Background: Activins

Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.

Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B).