金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Chk2 Long Name: Checkpoint Kinase 2 Aliases: CDS1; CHEK2; HuCds1; LFS2; PP1425; Rad53 Entrez Gene IDs: 11200 (Human); 50883 (Mouse); 114212 (Rat) Background: Chk2 The Chk2 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle checkpoints. In response to genotoxic insults Chk2 is phosphorylated by ATM or ATM-related kinases. Phosphorylation of Chk2 T68 promotes the formation of Chk2 oligomers. Oligomerization is a critical event in the activation of the Chk2 kinase as it is required for phosphorylation of additional Chk2 residues that lead to full activation and signaling to downstream effectors.