金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: UNC5H1 Long Name: Netrin Receptor UNC5A Aliases: UNC5A Entrez Gene IDs: 90249 (Human); 60629 (Rat) Background: UNC5H Family Members of the UNC5H family are best known as receptors for the axon guidance molecule netrin. Structurally, UNC5Hs have two Ig and two thrombospondin type 1 domains in their extracellular region, and a conserved ZU-5 domain, a deleted in colorectal cancer (DCC)-binding domain, and a C-terminal death domain in their cytoplasmic region. In general, they mediate the chemorepulsive effects of netrin, while the other netrin receptor subtype, DCC, mediates attraction. Members of the UNC5H family have also been implicated as tumor suppressors and regulators of apoptosis.