货号：13-124

品牌：Merck Millipore

规格：

目录价：￥4641.00

市场价格：￥3944.85

会员价格：￥3712.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: IRS1 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 20 µg View All» Product Overview: N-terminal 6His-tagged, recombinant rat IRS1, expressed in Sf9 cells. View All» Key Applications: Western Blotting View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).SIZE: 1242 amino acids; 131591 Da SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain. View All» Species: Rat View All» Molecular Weight: 165 kDa (including 6His-Tag) View All» Brand Family: Upstate View All» Source: Rat IRS1 expressed in Sf9 cells. View All» Presentation: 50mM Tris-HCl, 150mM NaCl, 250mM Imidazole, pH7.5, and 10% glycerol View All» Storage Conditions: Stable at -70°C for up to 1 year from date of receipt. View All» Gene Symbol:

• IRS1

• IRS-1

• HIRS-1
  View All» Product Name: IRS1 View All» Alternate Names: Insulin Receptor Substrate 1; pp185 View All» Quality Assurance: Routinely evaluated by detecting IRS1 with anti-IRS1 (Cat. No. 06-248 or 06-526) View All» Physical Form: Frozen liquid View All» UniProt Number: P35568 View All» Entrez Gene Number: NM_005544 View All» Purity: Purity >50%, determined by SDS-PAGE and Coomassie blue staining. View All»
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