货号：14-1048

品牌：Merck Millipore

规格：1EA

目录价：￥5611.82

市场价格：￥4770.05

会员价格：￥4489.46

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Human recombinant CARM1 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells. View All» Key Applications: Histone Methyltransferase Assay (HMT) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q86X55 # Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.SIZE: 585 amino acids; 63460 Da SUBUNIT: Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, CREBBP and CTNNB1. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.SUBCELLULAR LOCATION: Nucleus. Cytoplasm.TISSUE SPECIFICITY: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.SIMILARITY: SwissProt: Q86X55 ## Belongs to the protein arginine N-methyltransferase family. MISCELLANEOUS: Methylation of H3-R17 by CARM1 is stimulated by preacetylation of H3-K18/H3-K23 by EP300 and blocked by citrullination of H3-R17 by PADI4 (By similarity). View All» Molecular Weight: ~66 kDa View All» Brand Family: Upstate View All» Source: Human View All» Storage Conditions: 6 months at -80°C. View All» Replaces: 14-575 View All» Gene Symbol:

• CARM1

• PRMT4
  View All» Product Name: Human recombinant CARM1 View All» Quality Assurance: routinely evaluated by methylation of histone H3 View All» UniProt Number: Q86X55 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_199141.1 View All» Purity: Varies by lot; see lot-specific datasheet for information on each lot. View All»
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