货号：14-1055

品牌：Merck Millipore

规格：50Ug

目录价：￥5635.00

市场价格：￥4789.75

会员价格：￥4508.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Human recombinant histone H2AX-H2B dimers View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Human recombinant histone H2AX-H2B dimers expressed in E Coli. as fusion proteins with either an N-terminal FLAG® or 6xHis epitopes, and purified by Fast Protein Liquid Chromatography (FPLC) View All» Background Information: The core histones, H2A, H2B, H3, and H4, form a central octameric structure that binds approximately 147 bp of DNA to form a nucleosome, the basic unit of chromatin. The H2AX histone variant replaces conventional H2A in a subset of nucleosomes. H2AX plays a central role in DNA repair and genome stability. It prevents progression of the cell cycle in response DNA damage by ionizing radiation, and facilitates repair of double-stranded breaks in DNA. Phosphorylation of H2AX at serine 140 is required for its function as a hub for numerous signaling proteins involved in DNA damage and repair. The effects of histone variants and histone modifications can be deciphered by applications such as chromatin immunoprecipiation (ChIP), which requires high quality chromatin and essential tools, such as histone proteins and appropriate enzymes, to assemble chromatin in vitro. View All» Key Applications: Activity Assay View All» Application Notes: Suitable for in vitro chromatin assembly and enzyme activity assays View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Brand Family: Upstate View All» Source: Human View All» Presentation: In buffer containing 20 mM Tris-Cl pH 7.9, 1 mM EDTA, 2 M NaCl, 0.5 mM PMSF and 1 mM DTT View All» Host: E. coli View All» Storage Conditions: Stable at -80ºC for 1 year from date of receipt. View All» Product Name: Human recombinant histone H2AX-H2B dimers View All» Concentration: 1 µg/µL View All» Purity: >98% purity by SDS PAGE View All»