货号：14-1057

品牌：Merck Millipore

规格：1EA

目录价：￥6568.69

市场价格：￥5583.39

会员价格：￥5254.95

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Human native nucleosomes View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 20 µg View All» Product Overview: Human native nucleosomes purified from HeLa cell nuclei, digested with micrococcal nuclease, and purified by glycerol gradient and ion exchange chromatography. View All» Background Information: Nucleosomes are the basic units of chromatin, and are comprised of approximately 147 bp of DNA spooled around a central octamer of core histones, H2A, H2B, H3, and H4. The arrangement of nucleosomes in chromatin can be altered by post-translational modifications (PTM) occurring on the C- and N-terminal tails of the core histones. Histone modifications can either provide or hinder access of key transcriptional complexes to DNA sequences and can regulate the expression of genes. These effects can be deciphered by applications such as chromatin immunoprecipiation (ChIP), which requires high quality chromatin, and essential tools such as histone proteins and appropriate enzymes, to assemble chromatin in vitro. View All» Key Applications: Activity Assay View All» Application Notes: Suitable for in vitro chromatin assembly and enzyme activity assays View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Brand Family: Upstate View All» Source: Human View All» Presentation: In buffer containing 20 mM Tris-Cl pH 7.9, 1 mM EDTA, 2 M NaCl, 0.5 mM PMSF,1 mM DTT, and 50% glycerol View All» Storage Conditions: Stable at -80ºC for 1 year from date of receipt. View All» Product Name: Human native nucleosomes View All» Concentration: 0.2 µg/µL View All» Purity: >98% purity by SDS PAGE View All»