货号：14-109

品牌：Merck Millipore

规格：EA

目录价：￥12360.00

市场价格：￥10506.00

会员价格：￥9888.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PTP-1B, active, agarose conjugate View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Dephosphorylates tyrosine-phosphorylated peptides and proteins View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. View All» UniProt Summary: FUNCTION: SwissProt: P18031 # May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity).SIZE: 435 amino acids; 49967 Da SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.PTM: Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.SIMILARITY: SwissProt: P18031 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. & Contains 1 tyrosine-protein phosphatase domain. View All» Species: Human View All» Molecular Weight: 76kDa View All» Brand Family: Upstate View All» Source: GST-fusion to full-length human PTP-1B expressed in E. coli. View All» Protein Target: PTP-1B View All» Storage Conditions: 1 year at -20 C View All» Target Sub-Family: Tyr phosphatase View All» Gene Symbol:

• PTPN1

• PTP-1B

• PTP1B
  View All» Product Name: PTP-1B, active, agarose conjugate View All» Quality Assurance: routinely evaluated by measuring the hydrolysis of p-nitrophenyl phosphate (pNPP) View All» UniProt Number: P18031 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_002827.2 View All» Purification Method: Glutathione-agarose View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-140218.htm
  © Merck Millipore代理14-109 PRT TYR PHOSPHATASE IB PTP-1B 50UG，产品报价联系微信jinshanbio