货号：14-111

品牌：Merck Millipore

规格：

目录价：￥4926.00

市场价格：￥4187.10

会员价格：￥3940.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PP2A, purified View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 units View All» Product Overview: For selective in vitro dephosphorylation of proteins. View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. View All» UniProt Summary: FUNCTION: SwissProt: P30153 # The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.SIZE: 589 amino acids; 65309 Da SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.DOMAIN: SwissProt: P30153 Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family. & Contains 15 HEAT repeats. View All» Species: Human View All» Molecular Weight: 60kDa (A) and 36kDa (C) subunits View All» Brand Family: Upstate View All» Source: Purified from human red blood cells. View All» Protein Target: PP2A View All» Storage Conditions: 1 year at -20 C View All» Target Sub-Family: Ser/Thr phosphatase View All» Gene Symbol:

• PPP2R1A

• PR65A

• MGC786
  View All» Product Name: PP2A, purified View All» Quality Assurance: routinely evaluated by dephosphorylation of proteins View All» UniProt Number: P30153 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_014225.3 View All» Purification Method: DEAE chromatography, aminohexyl-agarose and gel filtration chromatography View All»
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