货号：14-305

品牌：Merck Millipore

规格：

目录价：￥4083.00

市场价格：￥3470.55

会员价格：￥3266.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: AMPK, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 units View All» Product Overview: Holoenzyme comprised of 3 subunits. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: Q13131 # Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.COFACTOR: Magnesium.SIZE: 550 amino acids; 62808 Da SUBUNIT: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1.SIMILARITY: SwissProt: Q13131 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. & Contains 1 protein kinase domain. View All» Species: Rat View All» Brand Family: Upstate View All» Source: Partially purified from rat liver. View All» Protein Target: AMPK View All» Storage Conditions: 1 year at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PRKAA1

• MGC57364

• AMPK

• MGC33776

• AMPKa1

• AMPK1
  View All» Product Name: AMPK, active View All» Quality Assurance: Routinely evaluated by phosphorylation of SAMS substrate peptide View All» UniProt Number:
  • Q13131

  • P54646
    View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
    • NM_006251.5

    • NM_206907.3
      View All» Purification Method: 2.5%-6.0% PEG, DEAE Sepharose™, Blue Sepharose™, 50% Ammonium Sulfate, Q-Sepharose™ and Sephacryl™ S200 chromatography. View All»
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