货号：14-309

品牌：Merck Millipore

规格：50Ug

目录价：￥7814.00

市场价格：￥6641.90

会员价格：￥6251.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PCAF, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Recombinant GST fusion protein View All» Key Applications: Histone Acetyltransferase Assay (HAT) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. View All» UniProt Summary: FUNCTION: SwissProt: Q92831 # Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.SIZE: 832 amino acids; 93013 Da SUBUNIT: Interacts with SIRT1 (By similarity). Interacts with EP300 and CREBBP. Interacts with NCOA1 and NCOA3. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat.SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle.DOMAIN:SwissProt: Q92831 The bromodomain mediates binding to HIV-1 Tat.SIMILARITY: Belongs to the GCN5 family. & Contains 1 bromo domain. & Contains 1 N-acetyltransferase domain. View All» Molecular Weight: 79kDa View All» Brand Family: Upstate View All» Source: expressed in E. Coli corresponding to amino acids 352-832 View All» Storage Conditions: 6 months at -20°C View All» Gene Symbol:

• PCAF

• GCN5

• GCN5L

• P

• P/CAF

• CAF
  View All» Product Name: PCAF, active View All» Quality Assurance: routinely evaluated by acetylation of core histones in vitro View All» UniProt Number: Q92831 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_003884.3 View All»
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  © Merck Millipore代理14-309 PCAF Protein, Active, 50 µg;store at -20℃，产品报价联系微信jinshanbio