货号：14-332

品牌：Merck Millipore

规格：

目录价：￥5623.00

市场价格：￥4779.55

会员价格：￥4498.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: SGK1 (S422D), unactive View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 25 µg View All» Product Overview: N-truncated (missing Nterminal 59 amino acids), N-terminal 6His-tagged, human SGK1 fusion protein, containing an S422D mutation View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition. View All» UniProt Summary: FUNCTION: SwissProt: O00141 # Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.SIZE: 431 amino acids; 48942 Da SUBUNIT: Interacts with NEDD4 and NEDD4L.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation.TISSUE SPECIFICITY: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung.PTM: Regulated by phosphorylation. Phosphoinositide 3-kinase (PI3- kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1. & Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells.SIMILARITY: SwissProt: O00141 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 48kDa View All» Brand Family: Upstate View All» Source: expressed in Sf21 cells View All» Protein Target: SGK1 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: AGC View All» Gene Symbol:

• SGK

• SGK1
  View All» Product Name: SGK1 (S422D), unactive View All» Quality Assurance: routinely evaluated by phosphorylation of Akt/SGK Substrate View All» UniProt Number: O00141 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NP_005618 View All» Purification Method: Ni-NTA agarose View All»
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