货号：14-343

品牌：Merck Millipore

规格：100Ug

目录价：￥4743.00

市场价格：￥4031.55

会员价格：￥3794.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: FKHR View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: N-terminal, Glutathione-Stransferase (GST) tagged, full-length fusion protein corresponding to human FKHR View All» Key Applications:

• Kinase Assay

• Western Blotting
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. View All» UniProt Summary: FUNCTION: SwissProt: Q12778 # Transcription factor.SIZE: 655 amino acids; 69662 Da SUBUNIT: Interacts with LRPPRC (By similarity).SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.TISSUE SPECIFICITY: Ubiquitous.PTM: Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Thr-24, Ser-256 and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser- 329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE: SwissProt: Q12778 # Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.SIMILARITY: SwissProt: Q12778 ## Contains 1 fork-head DNA-binding domain. View All» Species: Human View All» Molecular Weight: 105kDa View All» Brand Family: Upstate View All» Source: Recombinant human expressed in E. coli View All» Storage Conditions: 1 year at -70°C View All» Gene Symbol:
  • FOXO1

  • FKHR

  • FKH1

  • FOXO1A
    View All» Product Name: FKHR View All» Quality Assurance: routinely evaluated by phosphorylation by Akt1 View All» UniProt Number: Q12778 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_002015.3 View All» Purification Method: Glutathione-agarose View All»
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