货号：14-377M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MKK4/SKK1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal GST tagged, murine MKK4 residues 34-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. View All» UniProt Summary: FUNCTION: SwissProt: P45985 # Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).SIZE: 399 amino acids; 44288 Da SUBUNIT: Interacts with SPAG9 (By similarity).TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity).SIMILARITY: SwissProt: P45985 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain. View All» Species: Mouse View All» Molecular Weight: 67.7kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: MKK4 View All» Storage Conditions: 6 months at -70C View All» Target Sub-Family: STE View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MAP2K4

• MKK4

• JNKK

• MEK4

• MAPKK4

• JNKK1

• SEK1

• SERK1

• PRKMK4
  View All» Product Name: MKK4/SKK1, active View All» Quality Assurance: routinely evaluated by phosphorylation of ATF2 substrate View All» UniProt Number: P45985 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-377) and in bulk (cat# 14-377-K). View All» Entrez Gene Number: NM_003010.2 View All» Purification Method: Purified using glutathione agarose. Activated by incubation with MEKK and then re-purified using Ni2+/NTA agarose View All»
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