货号：14-405

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Lambda Protein Phosphatase View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 20000 units View All» Product Overview: Full-length, recombinant Lambda Protein Phosphatase (λ-PPase) with a C- terminal His-tag from the 221 amino-acid product from ORF221 of bacteriophage lambda.λ-PPase is a Mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosine and histidine residues. View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P49593 # Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.COFACTOR: Binds 2 magnesium or manganese ions per subunit (By similarity).SIZE: 454 amino acids; 49831 Da SUBUNIT: Associates with F1Aalpha.SIMILARITY: SwissProt: P49593 ## Belongs to the PP2C family. View All» Species: Bacteriophage lambda View All» Molecular Weight: 25kDa View All» Brand Family: Upstate View All» Protein Target: Lambda Protein Phosphatase View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: Ser/Thr/Tyr/His phosphatase View All» Gene Symbol:

• PPM1F

• FEM-2

• POPX2

• hFEM-2

• CaMKPase

• Ca

• KIAA0015
  View All» Product Name: Lambda Protein Phosphatase View All» Quality Assurance: Routinely evaluated by dephosphorylation of p-nitrophenyl phosphate (pNPP) View All» UniProt Number: P49593 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_014634.2 View All» Purification Method: Immobilized metal affinity chromatography (IMAC) View All»
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