货号:14-445M
品牌:Merck Millipore
规格:1ea
目录价:¥42566.00
市场价格:¥36181.10
会员价格:¥34052.80
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Description:
Casein Kinase 2α, active
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
250 µg
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Product Overview:
6His-tagged recombinant fulllength Casein Kinase 2α, human
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Key Applications:
Kinase Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
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UniProt Summary:
FUNCTION: SwissProt: P67870 # Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.SIZE: 215 amino acids; 24942 Da SUBUNIT: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.PTM: Phosphorylated by alpha subunit.SIMILARITY: SwissProt: P67870 ## Belongs to the casein kinase 2 subunit beta family.
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Species:
Human
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Molecular Weight:
48.7kDa
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Brand Family:
Upstate
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Source:
Expressed in Sf21
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Protein Target:
CK2α
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Storage Conditions:
1 year at -20°C
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Target Sub-Family:
CMGC
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Gene Symbol:
-
CSNK2B
-
Phosvitin
-
CK2B
-
CSK2B
-
MGC138224
-
MGC138222
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CK2N
-
G5a
-
phosvitin
-
G5A
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Product Name:
Casein Kinase 2α, active
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Quality Assurance:
Casein Kinase 2 Substrate Peptide
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UniProt Number:
P68400
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Packaging:
Also available in 10 μg size (cat#14-445) and in bulk (cat# 14-445-K).
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Purification Method:
Ni2+/NTA-agarose
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