货号：14-450M

品牌：Merck Millipore

规格：1EA

目录价：￥38599.60

市场价格：￥32809.66

会员价格：￥30879.68

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Cdk1/cyclin B, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: C-terminal His6-tagged human full length cdk1, and N-terminal GST-tagged human full length cyclin B View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. View All» UniProt Summary: FUNCTION: SwissProt: P06493 # Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.SIZE: 297 amino acids; 34095 Da SUBUNIT: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with DLG7. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.SUBCELLULAR LOCATION: Nucleus (By similarity).SIMILARITY: SwissProt: P06493 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 35kDa (cdk1) and 75kDa (cyclin B) View All» Brand Family: Upstate View All» Source: expressed individually by baculovirus in Sf21 insect cells View All» Protein Target: CDK1/cyclinB View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CMGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• CDC2

• CDK1

• MGC111195

• DKFZp686L20222

• CDC28A
  View All» Product Name: Cdk1/cyclin B, active View All» Quality Assurance: routinely evaluated by phosphorylation of the Histone H1 substrate View All» UniProt Number: P06493 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-450) and in bulk (cat# 14-450-K). View All» Entrez Gene Number:
  • NM_001786.2

  • NM_033379.2
    View All» Purification Method: Purified using Ni²⁺/NTA-agarose and GST-agarose, respectively. The cdk1 is then activated using CAK and repurified by Q Sepharose™ and Ni2+/NTA-agarose View All»
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