货号：14-458M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CSK, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: Recombinant full-length human CSK, containing an N-terminal GST-tag incorporating a PreScission Protease cleavage site View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: P41240 # Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.SIZE: 450 amino acids; 50704 Da SUBUNIT: Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic, also present in lipid rafts (By similarity).TISSUE SPECIFICITY: Expressed in lung and macrophages.PTM: Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.SIMILARITY: SwissProt: P41240 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Species: Human View All» Molecular Weight: 77.6kDa View All» Brand Family: Upstate View All» Source: Expressed in E. coli BL21 (DE3) cells View All» Protein Target: CSK View All» Storage Conditions: 1 year at -20°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• CSK

• MGC117393
  View All» Product Name: CSK, active View All» Quality Assurance: routinely evaluated by phosphorylation of Poly (Glu4Tyr) substrate peptide View All» UniProt Number: P41240 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-458) and in bulk (cat# 14-458-K). View All» Entrez Gene Number: NM_004383.1 View All» Purification Method: GSH-agarose chromatography View All»
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