货号：14-467M

品牌：Merck Millipore

规格：

目录价：￥35565.00

市场价格：￥30230.25

会员价格：￥28452.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PDGFRα, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: Recombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. View All» UniProt Summary: FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.SIZE: 1089 amino acids; 122670 Da SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 63.5kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PDGFRα View All» Storage Conditions: 1 year at -70°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PDGFRA

• CD140a

• PDGF-R-alpha

• MGC74795

• PDGFR2

• Rhe-PDGFRA

• CD140A
  View All» Product Name: PDGFRα, active View All» Quality Assurance: Routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide View All» UniProt Number: P16234 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 50 μg size (cat#14-467) and in bulk (cat# 14-467-K). View All» Entrez Gene Number: NM_006206.3 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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