货号：14-476M

品牌：Merck Millipore

规格：476M

目录价：￥38599.60

市场价格：￥32809.66

会员价格：￥30879.68

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Cdk7/Cyclin H/MAT1 (CAK complex), active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: Complex of recombinant full length human cdk7, containing a C-terminal His6-tag, recombinant full-length human cyclin H untagged and recombinant full-length human MAT1 containing an N-terminal GST-tag View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. View All» UniProt Summary: FUNCTION: SwissProt: P50613 # Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.SIZE: 346 amino acids; 39038 Da SUBUNIT: Associates primarily with cyclin H and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Interacts with PUF60.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous.PTM: Phosphorylation of Ser-164 during mitosis inactivates the enzyme. & Phosphorylation of Thr-170 is required for activity.SIMILARITY: SwissProt: P50613 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 39.9kDa (cdk7), 37.8kDa (cyclin H), 62.8kDa (MAT1). View All» Brand Family: Upstate View All» Source: All are expressed by baculovirus in Sf21 insect cells View All» Protein Target: CDK7/cyclinH/MAT1 View All» Storage Conditions: 1 year at -70°C View All» Target Sub-Family: CMGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• CDK7

• p39MO15

• CAK

• CAK1

• MO15

• CDKN7

• STK1
  View All» Product Name: Cdk7/Cyclin H/MAT1 (CAK complex), active View All» Quality Assurance: routinely evaluated by phosphorylation of cdk7 substrate peptide View All» UniProt Number: P50613 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-476) and in bulk (cat# 14-476-K). View All» Entrez Gene Number: NM_001799.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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