货号:14-492M
品牌:Merck Millipore
规格:250Ug
目录价:¥42566.00
市场价格:¥36181.10
会员价格:¥34052.80
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Description:
GSK3α, active
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
250 µg
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Product Overview:
N-terminal His6-tagged, recombinant amino acids 2-end of human GSK3α
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Key Applications:
Kinase Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
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UniProt Summary:
FUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).SIZE: 483 amino acids; 50981 Da SUBUNIT: Monomer (By similarity).SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
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Species:
Human
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Molecular Weight:
55kDa
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Brand Family:
Upstate
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Source:
Expressed in Sf21 cells
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Protein Target:
GSK3α
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Storage Conditions:
1 year at -70°C
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Target Sub-Family:
CMGC
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Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
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Gene Symbol:
-
GSK3A
-
DKFZp686D0638
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Product Name:
GSK3α, active
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Quality Assurance:
Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2 (GSK3 Substrate)
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UniProt Number:
P49840
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Packaging:
Also available in 10 μg size (cat#14-492) and in bulk (cat# 14-492-K).
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Entrez Gene Number:
NM_019884.2
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Purification Method:
Ni2+/NTA-agarose
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