货号：14-497

品牌：Merck Millipore

规格：10Ug

目录价：￥5382.00

市场价格：￥4574.70

会员价格：￥4305.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PKC η, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal His6-tagged, recombinant amino acids 2-end, of human PKC eta.PKC Lipid activator (Catalog # 20-133) is required for use. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. View All» UniProt Summary: FUNCTION: SwissProt: P24723 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.SIZE: 682 amino acids; 77563 Da TISSUE SPECIFICITY: Most abundant in lung, less in heart and skin.DOMAIN: SwissProt: P24723 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.DISEASE: SwissProt: P24723 # Defects in PRKCH may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 78.6kDa View All» Brand Family: Upstate View All» Source: Human PKC eta expressed in Sf21 cells. View All» Protein Target: PKCη View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: AGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PRKCH

• PRKCL

• PKCL

• MGC26269

• nPKC-eta

• MGC5363

• PKC-L
  View All» Product Name: PKC η, active View All» Quality Assurance: Routinely evaluated by phosphorylation of PKC Substrate Peptide View All» UniProt Number: P24723 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-497M when ordering the 250 µg size. View All» Entrez Gene Number: NM_006255.3 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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