货号：14-504M

品牌：Merck Millipore

规格：

目录价：￥35565.00

市场价格：￥30230.25

会员价格：￥28452.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PKCδ, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged, recombinant amino acids 2-end, of human PKCδPKC Lipid activator (Catalog # 20-133) is required for use. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. View All» UniProt Summary: FUNCTION: SwissProt: Q05655 # This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function.SIZE: 676 amino acids; 77477 Da SUBUNIT: Interacts with PDK1 (By similarity). Interacts with RAD9A and CDCP1.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).DOMAIN: SwissProt: Q05655 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor. & The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.PTM: Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 78.7kDa View All» Brand Family: Upstate View All» Source: Human PKCδ expressed in Sf21 cells. View All» Protein Target: PKCδ View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: AGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PRKCD

• MGC49908

• MAY1

• nPKC-delta
  View All» Product Name: PKCδ, active View All» Quality Assurance: Routinely evaluated by phosphorylation of PKC Substrate Peptide View All» UniProt Number: Q05655 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-504) and in bulk (cat# 14-504-K). View All» Entrez Gene Number:
  • NM_006254.3

  • NM_212539.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-141009.htm
    © Merck Millipore代理14-504M PKC delta, active BULK SIZE 250ug，产品报价联系微信jinshanbio