货号:14-519
品牌:Merck Millipore
规格:10Ug
目录价:¥6586.00
市场价格:¥5598.10
会员价格:¥5268.80
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Description:
Cdk6/Cyclin D3, active
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
10 µg
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Product Overview:
N-terminal, His6-tagged fulllength human cdk6 complexed with N-terminal GSTtagged full-length human cyclin D3
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Key Applications:
Kinase Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
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UniProt Summary:
FUNCTION: SwissProt: Q00534 # Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.SIZE: 326 amino acids; 36938 Da SIMILARITY: SwissProt: Q00534 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
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Species:
Human
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Molecular Weight:
38kDa (cdk6) and 59kDa (cyclin D3)
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Brand Family:
Upstate
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Source:
expressed in Sf21 cells
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Protein Target:
CDK6/cyclinD3
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Storage Conditions:
6 months at -70°C
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Target Sub-Family:
CMGC
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Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
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Gene Symbol:
-
CDK6
-
PLSTIRE
-
MGC59692
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Product Name:
Cdk6/Cyclin D3, active
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Quality Assurance:
routinely evaluated by phosphorylation of histone H1
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UniProt Number:
Q00534
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Packaging:
Also available in 250μg size as catalog # 14-519M - Call for pricing and availability.
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Entrez Gene Number:
NM_001259.5
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Purification Method:
Glutathione-agarose
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