货号：14-524

品牌：Merck Millipore

规格：10Ug

目录价：￥6618.00

市场价格：￥5625.30

会员价格：￥5294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MST2, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal His6-tagged recombinant human MST2 residues 2-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q13188 # Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates TITF1 (By similarity). Phosphorylates and activates LATS1 and LATS2.COFACTOR: Magnesium.SIZE: 491 amino acids; 56301 Da SUBUNIT: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation (By similarity). Interacts with and stabilizes SAV1. Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1, which leads to enzyme activation.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity).TISSUE SPECIFICITY: Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.SIMILARITY: SwissProt: Q13188 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain. & Contains 1 SARAH domain. View All» Species: Human View All» Molecular Weight: 57.2kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 insect cells View All» Protein Target: MST2 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: STE View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• STK3

• MST-2

• FLJ90748

• MST2

• KRS1
  View All» Product Name: MST2, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP View All» UniProt Number: Q13188 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-524M when ordering the 250 µg size. View All» Entrez Gene Number: NM_006281.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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