货号：14-540M

品牌：Merck Millipore

规格：

目录价：￥30125.00

市场价格：￥25606.25

会员价格：￥24100.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Tie2, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged recombinant human Tie2 residues 771-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. View All» UniProt Summary: FUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.SIZE: 1124 amino acids; 125811 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 42kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 insect cells View All» Protein Target: Tie2 View All» Storage Conditions: 6 months at -70C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• TEK

• CD202B

• TIE2

• VMCM1

• VMCM

• hTIE2

• CD202b

• TIE-2
  View All» Product Name: Tie2, active View All» Quality Assurance: routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) View All» UniProt Number: Q02763 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-540) and in bulk (cat# 14-540-K). View All» Entrez Gene Number: NM_000459.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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