货号：14-542

品牌：Merck Millipore

规格：50Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MKK7β1, unactive View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. View All» UniProt Summary: FUNCTION: SwissProt: O14733 # Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.COFACTOR: Magnesium.SIZE: 419 amino acids; 47485 Da SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).TISSUE SPECIFICITY: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.PTM: Activated by phosphorylation on Ser/Thr.SIMILARITY: SwissProt: O14733 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 74kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: MKK7β1 View All» Storage Conditions: 6 months at -20°C View All» Target Sub-Family: STE View All» Gene Symbol:

• MAP2K7

• MKK7

• PRKMK7

• MEK7

• MAPKK7

• JNKK2

• Jnkk2
  View All» Product Name: MKK7β1, unactive View All» Quality Assurance: routinely evaluated by phosphorylation of ATF2 (amino acids 19-96) View All» UniProt Number: O14733 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_145185.2 View All» Purification Method: Glutathione-agarose View All»
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