货号：14-545M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: NEK2, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged, recombinant, full-length, human NEK2 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: P51955 # Protein kinase that is involved in mitotic regulation. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.COFACTOR: Magnesium.SIZE: 445 amino acids; 51763 Da SUBUNIT: Interacts with TERF1. Isoform 1 and isoform 2 form homo- and heterodimers.SUBCELLULAR LOCATION: Nucleus. & Isoform 1: Nucleus, nucleolus. Note=Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end. & Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic.TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types.DEVELOPMENTAL STAGE: Accumulates throughout S phase and shows maximal levels in late G2. This expression pattern is highly reminiscent of that of A and B cyclins. Expression of both isoform 1 and isoform 2 is low in the G1 phase and increases in the S/G2 phases. Isoform 1 is absent from cells arrested in the G2/M prometaphase, whereas isoform 2 remains present.SIMILARITY: SwissProt: P51955 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 52.8kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 cells View All» Protein Target: NEK2 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: Misc View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• NEK2

• NLK1

• NLK

• NEK2A

• HsPK21
  View All» Product Name: NEK2, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP View All» UniProt Number: P51955 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-545) and in bulk (cat# 14-545-K). View All» Entrez Gene Number: NM_002497.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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