货号：14-547M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CaM Kinase IV, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: C-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. View All» UniProt Summary: FUNCTION: SwissProt: Q16566 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory (By similarity).SIZE: 473 amino acids; 51926 Da SUBUNIT: Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix (By similarity).TISSUE SPECIFICITY: Expressed in epithelial ovarian cancer tissue.PTM: Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.SIMILARITY: SwissProt: Q16566 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 52.9kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 insect cells View All» Protein Target: CaMKIV View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• CAMK4

• MGC36771

• CaMK-GR
  View All» Product Name: CaM Kinase IV, active View All» Quality Assurance: routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide View All» UniProt Number: Q16566 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-547) and in bulk (cat# 14-547-K). View All» Entrez Gene Number: NM_001744.3 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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