货号：14-551

品牌：Merck Millipore

规格：10Ug

目录价：￥5543.00

市场价格：￥4711.55

会员价格：￥4434.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Fms, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. View All» UniProt Summary: FUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.SIZE: 972 amino acids; 107984 Da SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 50.2kDa View All» Brand Family: Upstate View All» Source: Human Fms expressed by baculovirus in Sf21 insect cells View All» Protein Target: Fms View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• CSF1R

• FIM2

• CSF-1-R

• C-FMS

• CSFR

• c-fms

• CD115

• FMS
  View All» Product Name: Fms, active View All» Quality Assurance: Routinely evaluated by phosphorylation of IGF-R1tide View All» UniProt Number: P07333 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-551M when ordering the 250 µg size. View All» Entrez Gene Number: NM_005211.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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