货号:14-554M
品牌:Merck Millipore
规格:1ea
目录价:¥42566.00
市场价格:¥36181.10
会员价格:¥34052.80
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Description:
EphB4, active
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
250 µg
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Product Overview:
N-terminal His6-tagged, recombinant, human EphB4, amino acids 561-end
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Key Applications:
Kinase Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
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UniProt Summary:
FUNCTION: SwissProt: P54760 # Receptor for members of the ephrin-B family. Binds to ephrin-B2. May have a role in events mediating differentiation and development.SIZE: 987 amino acids; 108270 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Abundantly expressed in placenta and in a range of primary tissues and malignant cell lines. Expressed in fetal, but not adult, brain, and in primitive and myeloid, but not lymphoid, hematopoietic cells.PTM: Autophosphorylated.SIMILARITY: SwissProt: P54760 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
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Species:
Human
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Molecular Weight:
51kDa
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Brand Family:
Upstate
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Source:
expressed by baculovirus in Sf21 insect cells
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Protein Target:
EphB4
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Storage Conditions:
6 months at -70°C
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Target Sub-Family:
TK
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Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
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Gene Symbol:
-
EPHB4
-
EphB4
-
TYRO11
-
MYK1
-
Tyro11
-
HTK
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Product Name:
EphB4, active
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Quality Assurance:
routinely evaluated by phosphorylation of poly (Glu, Tyr) (4:1)
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UniProt Number:
P54760
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Packaging:
Also available in 10 μg size (cat#14-554) and in bulk (cat# 14-554-K).
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Entrez Gene Number:
NM_004444.4
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Purification Method:
Ni2+/NTA-agarose
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