货号：14-558

品牌：Merck Millipore

规格：20Ug

目录价：￥6791.00

市场价格：￥5772.35

会员价格：￥5432.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI3 Kinase (p120γ) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 20 µg View All» Product Overview: N-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ). View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. View All» UniProt Summary: FUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.SIZE: 1102 amino acids; 126454 Da SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain. View All» Species: Human View All» Molecular Weight: 130kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PI3Kγ View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: PI3K/PI4K View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PIK3CG

• p110-gamma

• PI3-kinase

• PIK3

• PI3K

• PI3Kgamma

• PTDINS-3-kinase

• PI3CG

• p120-PI3K
  View All» Product Name: PI3 Kinase (p120γ) View All» Quality Assurance: Routinely evaluated in the PIProfiler. View All» UniProt Number: P48736 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size as catalog # 14-558M - Call for pricing and availability. View All» Entrez Gene Number: NM_002649.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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