货号：14-564

品牌：Merck Millipore

规格：10Ug

目录价：￥5382.00

市场价格：￥4574.70

会员价格：￥4305.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: SRPK1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GSTtagged recombinant human SRPK1 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q96SB4 # Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.COFACTOR: Magnesium.SIZE: 826 amino acids; 92407 Da SUBUNIT: Present in a seven component complex, the toposome, which separates entangled circular chromatin DNA during chromosome segregation. The extended N-terminal domain of isoform 1 binds to the nuclear scaffold-associated protein SAFB suggesting this isoform may phosphorylate splicing factors in close vicinity to the nuclear matrix.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Isoform 1 and isoform 2 are cytoplasmic and nuclear.TISSUE SPECIFICITY: Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2.SIMILARITY: SwissProt: Q96SB4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 100kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: SRPK1 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CMGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• SRPK1

• SFRSK1
  View All» Product Name: SRPK1, active View All» Quality Assurance: routinely evaluated by phosphorylation of SRPK1tide View All» UniProt Number: Q96SB4 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_003137.3 View All» Purification Method: Glutathione-agarose View All»
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