货号：14-572

品牌：Merck Millipore

规格：10Ug

目录价：￥6475.00

市场价格：￥5503.75

会员价格：￥5180.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PLK3, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal His6-tagged recombinant human Plk3, residues 19-301 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. View All» UniProt Summary: FUNCTION: SwissProt: Q9H4B4 # Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein.SIZE: 646 amino acids; 71629 Da SUBUNIT: Binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain.SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.TISSUE SPECIFICITY: Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.PTM: Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis (By similarity).SIMILARITY: SwissProt: Q9H4B4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. & Contains 2 POLO box domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 36kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 insect cells View All» Protein Target: PLK3 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: AGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PLK3

• CNK

• PLK-3

• FNK

• PRK
  View All» Product Name: PLK3, active View All» Quality Assurance: routinely evaluated by phosphorylation of Casein View All» UniProt Number: Q9H4B4 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-572M when ordering the 250 µg size. View All» Entrez Gene Number: NM_004073.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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