货号：14-574M

品牌：Merck Millipore

规格：

目录价：￥35565.00

市场价格：￥30230.25

会员价格：￥28452.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: EphA4, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged recombinant human EphA4 residues 601-892 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. View All» UniProt Summary: FUNCTION: SwissProt: P54764 # Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.SIZE: 986 amino acids; 109860 Da SUBUNIT: Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Ubiquitous.DOMAIN: SwissProt: P54764 The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain. View All» Species: Human View All» Molecular Weight: 37kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: EphA4 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• EPHA4

• Hek8

• HEK8

• EphA4

• TYRO1

• SEK
  View All» Product Name: EphA4, active View All» Quality Assurance: Routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) View All» UniProt Number: P54764 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-574) and in bulk (cat# 14-574-K). View All» Entrez Gene Number: NM_004438.3 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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