货号：14-585

品牌：Merck Millipore

规格：10Ug

目录价：￥4375.00

市场价格：￥3718.75

会员价格：￥3500.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MAPKAP Kinase 3, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: expressed in E. coli; activated using SAPK2a (Catalog #14-587) View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. View All» UniProt Summary: FUNCTION: SwissProt: Q16644 # Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.SIZE: 382 amino acids; 42987 Da SUBUNIT: Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.TISSUE SPECIFICITY: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.SIMILARITY: SwissProt: Q16644 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 69.8kDa View All» Brand Family: Upstate View All» Source: N-terminal GST-tagged, recombinant, human MAPKAP Kinase 3, amino acids 2-end View All» Protein Target: MAPKAP-K3 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MAPKAPK3

• MAPKAP

• MAPKAP3

• 3PK

• MAPKAPK-3

• 3pK
  View All» Product Name: MAPKAP Kinase 3, active View All» Quality Assurance: routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide (Catalog #12-240) View All» UniProt Number: Q16644 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-585M when ordering the 250 µg size. View All» Entrez Gene Number: NM_004635.3 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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