货号：14-593M

品牌：Merck Millipore

规格：

目录价：￥39747.00

市场价格：￥33784.95

会员价格：￥31797.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HePTP View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged, recombinant human HePTP, amino acid residues 22- end View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P35236 # Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.SIZE: 360 amino acids; 40529 Da SUBUNIT: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen.PTM: Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.SIMILARITY: SwissProt: P35236 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. & Contains 1 tyrosine-protein phosphatase domain. View All» Species: Human View All» Molecular Weight: 40.7kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: HePTP View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: Tyr phosphatase View All» Gene Symbol:

• PTPN7

• BPTP-4

• LC-PTP

• LPTP

• HEPTP

• PTPNI
  View All» Product Name: HePTP View All» Quality Assurance: routinely evaluated by dephosphorylation of 100μM DiFMUP View All» UniProt Number: P35236 View All» Specific Activity: For Specific Activity Data, refer to the Certificate of Analysis for individual lots of this enzyme View All» Packaging: Also available in 10 μg size (cat#14-593) and in bulk (cat# 14-593-K). View All» Entrez Gene Number:
  • NM_002832.2

  • NM_080588.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-141571.htm
    © Merck Millipore代理14-593M HEPTP 250ug，产品报价联系微信jinshanbio