货号：14-594M

品牌：Merck Millipore

规格：

目录价：￥39747.00

市场价格：￥33784.95

会员价格：￥31797.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: VHR View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal GST-tagged, recombinant VHR expressed in E. coli View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. View All» UniProt Summary: FUNCTION: SwissProt: P51452 # This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.SIZE: 185 amino acids; 20478 Da SIMILARITY: SwissProt: P51452 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 tyrosine-protein phosphatase domain. View All» Species: Human View All» Molecular Weight: 47.8kDa View All» Brand Family: Upstate View All» Source: recombinant human full-length VHR expressed in E. coli View All» Protein Target: VHR View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: Ser/Thr/Tyr phosphatase View All» Gene Symbol:

• DUSP3

• VHR
  View All» Product Name: VHR View All» Quality Assurance: routinely evaluated by phosphorylation of DiFMUP View All» UniProt Number: P51452 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-594) and in bulk (cat# 14-594-K). View All» Entrez Gene Number: NM_004090.2 View All» Purification Method: Glutathione-agarose View All»
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