货号：14-596

品牌：Merck Millipore

规格：10Ug

目录价：￥7078.00

市场价格：￥6016.30

会员价格：￥5662.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: LKB1/STRADα/MO25α, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: Recombinant full-length human LKB1 with an N-terminal 6His tag. Provided as a complex with GST-STRADα and GST-MO25α. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.COFACTOR: Magnesium or Manganese.SIZE: 433 amino acids; 48636 Da SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity).DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).SIMILARITY: SwissProt: Q15831 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 51/76/66kDa View All» Brand Family: Upstate View All» Source: expressed in Sf21 View All» Protein Target: LKB1 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• STK11

• PJS

• LKB1
  View All» Product Name: LKB1/STRADα/MO25α, active View All» Quality Assurance: Routinely evaluated by phosphorylation of LKBtide. View All» UniProt Number: Q15831 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_000455.4 View All» Purification Method: GSH agarose followed by Ni²⁺/NTA agarose View All»
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  © Merck Millipore代理14-596 LKB1/STRADα/MO25α Protein, active, 10 µg;LKB1/STRADα/MO25α 蛋白，活性，10 µgstore at -80℃，产品报价联系微信jinshanbio