货号：14-599M

品牌：Merck Millipore

规格：1ea

目录价：￥47391.00

市场价格：￥40282.35

会员价格：￥37912.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: IRAK4, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged, recombinant full length, human IRAK4 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Interleukin-1 receptor (see IL1R; MIM 147810)-associated kinases (e.g., IRAK1; MIM 300283) are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9NWZ3 # Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.COFACTOR: Magnesium.SIZE: 460 amino acids; 51530 Da SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.DISEASE: SwissProt: Q9NWZ3 # Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. & Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.SIMILARITY: SwissProt: Q9NWZ3 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 57.1kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: IRAK4 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TKL View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• IRAK4

• NY-REN-64

• REN64

• IRAK-4

• LOC51135

• IPD1
  View All» Product Name: IRAK4, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP (Catalog #13-104) View All» UniProt Number: Q9NWZ3 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-599) and in bulk (cat# 14-599-K). View All» Entrez Gene Number: NM_016123.1 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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  © Merck Millipore代理14-599M IRAK4 Protein, active, 10 µg;IRAK4蛋白，活性，10 µgstore at -80℃，产品报价联系微信jinshanbio