货号：14-633

品牌：Merck Millipore

规格：1ea

目录价：￥6618.00

市场价格：￥5625.30

会员价格：￥5294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PAK6, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal His6-tagged, recombinant, human PAK6, amino acids 382-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. View All» UniProt Summary: FUNCTION: SwissProt: Q9NQU5 # The activated kinase acts on a variety of targets (By similarity).SIZE: 681 amino acids; 74869 Da SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor.PTM: Autophosphorylated when activated by CDC42/p21 (By similarity).SIMILARITY: SwissProt: Q9NQU5 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 37.9kDa View All» Brand Family: Upstate View All» Source: baculovirus in Sf21 cells View All» Protein Target: PAK6 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: STE View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PAK6

• PAK-5

• PAK-6

• PAK5
  View All» Product Name: PAK6, active View All» Quality Assurance: routinely evaluated by phosphorylation of PAKtide View All» UniProt Number: Q9NQU5 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_020168.3 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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