货号：14-634

品牌：Merck Millipore

规格：10Ug

目录价：￥5229.00

市场价格：￥4444.65

会员价格：￥4183.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MuSK, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal His6-tagged, recombinant, human MuSK View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Intercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: O15146 # Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization (By similarity).SIZE: 869 amino acids; 97056 Da SUBUNIT: Interacts with DOK7, which probably regulates its activity (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).DISEASE: SwissProt: O15146 # Defects in MUSK is a cause of autosomal recessive congenital myasthenic syndrome (CMS) [MIM:608931]. Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. MUSK mutations lead to decreased agrin- dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.SIMILARITY: SwissProt: O15146 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 FZ (frizzled) domain. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 43.1kDa View All» Brand Family: Upstate View All» Source: human MuSK, amino acids 530-end, expressed by baculovirus in Sf21 cells View All» Protein Target: MuSK View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MUSK

• MuSK

• MGC126323

• MGC126324
  View All» Product Name: MuSK, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP (13-104) View All» UniProt Number: O15146 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_005592.1 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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